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Objective:To investigate the expressions and their relationship of pituitary tumor transforming gene(PTTG)and proliferating cell nuclear antigen (PCNA)in glioma.Methods:The protein expressions of PTTG and PCNA were detected by immunostaining assay using streptavidin-peroxidase(SP)method in 80 cases of glioma.Result:The positive rates of PTTG in grades Ⅰ-Ⅳ gliomas were 56.3%,68.2%,80.8%,and 100.0%respectively,and the protein expression of PTTG increased with the increasing of the pathological grade(X2=9.602,P＜0.05):The positive rates of PCNA protein were 37.5%,54.5%, 69.2%.and 93.8%respectively,and the protein expression of PCNA increased with the increasing of the pathological grade (X2=12.147.P＜0.01).The expression of PTTG had positive correlation with the expression of PCNA protein(Y8=0.557,P＜0.01).Conclusion:The expressions of PTTG and PCNA proteins were related to malignant degree of gtioma.and may cooperate with each other in the tumorigenesis and progression and can be considered as the indicators of the biological behaviors in glioma.