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目的探讨经皮冠状动脉介入(PCI)术后主要心血管事件(MACE)的独立危险因素。方法 123例PCI成功的冠心病患者进行术后规范抗栓治疗,同时中医辨证分为气虚血瘀组49例和非气虚血瘀组74例,7天后所有患者采血检测血小板计数(PLT)、最大血小板聚集率(MPA)、血浆遗传性假血友病因子(vWF)、血小板膜糖蛋白b/a(GPb/a)、凝血酶原片段1+2(F1+2)和纤维蛋白原(Fg),运用Logistic回归筛选出PCI术后1年MACE的独立危险因素。结果 PCI术后气虚血瘀组MPA、vWF、GPb/a高于非气虚血瘀组(P<0.05),而PLT、F1+2和Fg两组间差异无统计学意义(P>0.05)。结论 PCI术后气虚血瘀证仍存在明显的血小板活化和血管内皮损伤,是PCI术后MACE的独立危险因素之一。
Objective To investigate the independent risk factors of major cardiovascular events (MACE) after percutaneous coronary intervention (PCI). Methods A total of 123 patients with coronary heart disease undergoing PCI were given antithrombotic therapy. 49 cases of Qi-deficiency and blood-stasis group and 74 cases of non-Qi-deficiency and blood-stasis group were included in TCM syndrome differentiation. All patients were tested for platelet count (PLT) MPA, vWF, GPb / a, F + 2 (F + 2) and fibrinogen (Fg) ), Logistic regression was used to screen independent risk factors for MACE at 1 year after PCI. Results The levels of MPA, vWF and GPb / a in Qi-deficiency and blood-stasis group after PCI were significantly higher than those in non-Qi-deficiency and blood-stasis group (P <0.05), but there was no significant difference between PLT, F1 + 2 and Fg group (P> 0.05). Conclusion There is still significant platelet activation and vascular endothelial injury after PCI in Qi deficiency and blood stasis syndrome, which is one of the independent risk factors of MACE after PCI.