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目的观察硫辛酸联合前列地尔治疗糖尿病周围神经病变(DPN)的临床疗效。方法选取90例DPN患者随机分为常规治疗组(对照组,44例)和硫辛酸联合前列地尔治疗组(治疗组,46例),疗程3周,于治疗前后观察临床症状,腱反射和肌电图的变化。结果治疗组和常规治疗组的总有效率分别为86.9%和59.1%,差异有统计学意义(P<0.01)。结论硫辛酸联合前列地尔可有效改善DPN患者的临床症状,疗效显著,值得临床推广。
Objective To observe the clinical efficacy of lipoic acid combined with alprostadil in the treatment of diabetic peripheral neuropathy (DPN). Methods 90 DPN patients were randomly divided into routine treatment group (control group, 44 cases) and lipoic acid combined with alprostadil treatment group (46 cases), the course of treatment for 3 weeks, before and after treatment to observe the clinical symptoms, tendon reflex and EMG changes. Results The total effective rates of the treatment group and the conventional treatment group were 86.9% and 59.1%, respectively, with statistical significance (P <0.01). Conclusion Lipoic acid combined with alprostadil can effectively improve the clinical symptoms of patients with DPN, the effect is significant, worthy of clinical promotion.