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目的和方法：在甘油致大鼠急性肾功能衰竭（ＡＲＦ）模型上，观察外源内皮素（ＥＴ）以及心房钠尿肽（ＡＮＰ）、硝苯吡碇（Ｎｉｆ）和ＮＯ前体Ｌ－精氨酸（Ｌ－Ａｒｇ）的作用。结果：甘油致大鼠ＡＲＦ后２４ｈ，肾功能明显受损，血清尿素氮（ＳＵＮ），肌酐（Ｓｃｒ），丙二醛（ＭＤＡ），肾皮质钙含量及血浆内皮素（ＰＥＴ）水平均明显高于正常对照组（Ｐ＜０００１）。外源性ＥＴ可加重ＡＲＦ大鼠肾损伤，使ＳＵＮ、Ｓｃｒ、ＭＤＡ、ＰＥＴ及肾皮质钙含量显著增加，而ＡＮＰ、Ｎｉｆ和Ｌ－Ａｒｇ则使ＡＲＦ大鼠ＳＵＮ、Ｓｃｒ、ＭＤＡ、ＰＥＴ及肾皮质钙含量明显降低，肾组织ｃＧＭＰ含量增加，减轻肾小管损伤。结论：ＥＴ对ＡＲＦ的发生发展具有重要意义，ＡＮＰ、Ｎｉｆ和Ｌ－Ａｒｇ可通过不同途径拮抗ＥＴ的生物学效应，从而对ＡＲＦ的防治起到积极的作用。
AIM: To observe the effects of exogenous endothelin (ET), atrial natriuretic peptide (ANP), nifedipine (Nif) and NO precursor L-aspartate Amino acids (L-Arg) role. Results: The renal function was significantly impaired at 24h after glycerol-induced ARF in rats. The levels of serum urea nitrogen (SUN), creatinine (Scr), malondialdehyde (MDA), renal cortical calcium and plasma endothelin (PET) In the normal control group (P <0001). Exogenous ET increased renal injury in ARF rats and significantly increased the contents of SUN, Scr, MDA, PET and renal cortical calcium, while ANP, Nif and L-Arg increased the levels of SUN, Scr, MDA, PET and renal Cortical calcium content was significantly reduced, cGMP increased renal tissue content, reduce renal tubular injury. CONCLUSION: ET plays an important role in the development of ARF. ANP, Nif and L-Arg can antagonize the biological effects of ET through different pathways, and thus play an active role in the prevention and treatment of ARF.