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急性肺损伤(ALI)是全身炎症反应综合征在肺部的表现,可进一步发展为急性呼吸窘迫综合征(ARDS),其发病机制复杂,病死率高达35%～40%。在其复杂的发病机制中,失控的炎症反应中的炎症细胞、细胞因子和炎症介质所构成的“细胞网络”和“细胞因子网络”发挥重要作用,此外还有凝血/纤溶的失衡、氧化还原不平衡、细胞凋亡、水通道蛋白及个体差异、遗传因素的影响等参与这一过程。本文就近年来的研究做一阐述。
Acute lung injury (ALI) is a manifestation of systemic inflammatory response syndrome in the lungs and can be further developed into acute respiratory distress syndrome (ARDS). Its pathogenesis is complicated with a mortality rate of 35% -40%. In its complex pathogenesis, the “cellular networks” and “cytokine networks” formed by inflammatory cells, cytokines and inflammatory mediators in uncontrolled inflammatory responses play an important role in addition to coagulation / fibrinolysis Imbalance, redox imbalance, apoptosis, aquaporin and individual differences, the impact of genetic factors involved in this process. This article makes an elaboration on the research in recent years.