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曾报道烷基磷脂类化合物能抑制小鼠体内移植肿瘤的生长并能选择破坏白血病细胞。在Andreesen等所试的九种溶血磷脂化合物中,1-O-十八烷基-2-O-甲基甘油-3-磷脂胆碱(ET-18-OCH_3,1)具有杀死白血病癌细胞的最高能力。其作用机制可能是抑制后者的新陈代谢或活化巨噬细胞。
Alkyl phospholipids have been reported to inhibit tumor growth in mice transplanted in vivo and can choose to destroy leukemia cells. Among the nine lysophospholipids tested by Andreesen et al., 1-O-octadecyl-2-O-methylglycero-3-phospholipid choline (ET- 18-OCH 3,1) has the ability to kill leukemia cancer cells The highest ability. Its mechanism of action may be to inhibit the latter’s metabolism or activate macrophages.