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目的探讨苯磺酸氨氯地平联合赖诺普利治疗原发性高血压的疗效和安全性。方法将64例原发性高血压患者分为苯磺酸氨氯地平、赖诺普利联合组(A组)32例和单用氨氯地平组(B组)32例,用药24周后观察疗效。结果两组患者治疗后血压均较治疗前有明显改善,治疗前后比较差异具有统计学意义。苯磺酸氨氯地平、赖诺普利联合组治疗收缩压总有效率为90.6%,舒张压84.4%,单用氨氯地平组收缩压71.9%,舒张压65.6%,两者比较差异有统计学意义(P<0.05)。苯磺酸氨氯地平、赖诺普利联合组不良反应发生率为12.5%,单用氨氯地平组9.3%,两组间比较差异无统计学意义(P>0.05),左室重量指数(LVMI)较治疗前明显改善(P<0.05),A组较B组更明显(P<0.01)。结论苯磺酸氨氯地平联合赖诺普利具有明显的降压作用,对LVH逆转有协同作用,且不良反应少。
Objective To investigate the efficacy and safety of amlodipine besylate combined with lisinopril in the treatment of essential hypertension. Methods Sixty-four patients with essential hypertension were divided into amlodipine besylate, lisinopril combined group (group A) 32 and amlodipine alone group B (group B) 32 cases were observed after 24 weeks Efficacy. Results After treatment, the blood pressure in both groups was significantly improved compared with that before treatment, and the difference was statistically significant before and after treatment. Amlodipine besylate, lisinopril combined treatment of systolic blood pressure total effective rate was 90.6%, diastolic blood pressure 84.4%, amlodipine alone group systolic blood pressure 71.9%, diastolic blood pressure 65.6%, the difference between the two statistics Significance (P <0.05). Amlodipine besylate, lisinopril combined group 12.5% adverse reactions, with amlodipine alone 9.3%, no significant difference between the two groups (P> 0.05), left ventricular mass index LVMI) was significantly improved compared with that before treatment (P <0.05), and group A was more obvious than that of group B (P <0.01). Conclusion Amlodipine besylate combined with lisinopril has a significant antihypertensive effect, a synergistic effect on the reversal of LVH with few adverse reactions.