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原发性肝癌病因为多因素协同作用的结果，我国肝癌病因以乙型肝类病毒（HBV）、黄曲霉毒素B1（AFB1巳）、饮水污染和遗传等因素为主。某些微量元素缺乏，促进了肝癌的发生、发展。科学工作者针对肝癌病因采取以“防治肝炎、管粮防霉、改良饮水、适量补硒”为中心的综合防治措施，已取得初步成效，本研究进一步阐明在肝癌高发现场应用补硒预防肝癌的作用。通过四年前瞻研究结果表明，食硒盐补硒组较对照组血硒GSH－px升高，UDS、微核出现率减少．对乙型肝炎病毒感染率（HBsAg）下降，肝癌发病率有下降。趋势。两组肝肾功能阳性率无明显差异。提示在肝癌高发区，尤其是低硒地区适量补硒可以降低肝癌发病率。
Due to the multi-factor synergistic effect of primary liver cancer, the cause of liver cancer in China is dominated by hepatitis B virus (HBV), aflatoxin B1 (AFB1巳), drinking water contamination, and genetic factors. The lack of certain trace elements has promoted the occurrence and development of liver cancer. Scientific workers have taken comprehensive prevention and control measures centering on the causes of hepatocellular carcinoma, which include prevention and treatment of hepatitis, tuberculosis and mildew prevention, improved drinking water, and appropriate selenium supplementation. Preliminary results have been achieved. This study further clarified the application of selenium in the prevention of liver cancer. effect. According to the results of the four-year prospects, selenium-selenium supplemented selenium group had higher blood selenium GSH-px than the control group, and the UDS and micronucleus frequency were reduced. The incidence of Hepatitis B virus infection (HBsAg) decreased, and the incidence of liver cancer decreased. trend. There was no significant difference in the positive rate of liver and kidney function between the two groups. It is suggested that the appropriate amount of selenium in the high-incidence areas of liver cancer, especially in low selenium areas, can reduce the incidence of liver cancer.