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1989年7～10月．在海南省抗药性恶性疟流行区试用复方蒿甲醇16片／3d疗程治疗恶性疟33例，均获治愈。平均退热时间和原虫无性体转阴时间分别为25．71±16．84h和28．957．87h；药后24h平均减虫为9724±4．28％；2例带配子体者在7d消失，余31例均不出现配子体；随访28d，未出现复燃；药后不出现毒、副反应．结果表明，复方蒿甲醚治疗恶性疟有速效、高效、低毒的优点。对配子体的形成似有抑制作用．在抗药性恶性疟流行区有扩大使用的价值。
July to October 1989. In Hainan endemic area of drug-resistant falciparum malaria trial of compound artemether 16 / 3d course of treatment of 33 cases of falciparum malaria were cured. The mean time to pyrexia and protozoa ameloblastoma were 25.71 ± 16.84h and 28.957.87h, respectively. The mean reduction of worms was 9724 ± 4.28% at 24 hours after treatment. Two cases with gametophyte disappeared on day 7, No gametophyte was found in the remaining 31 cases. No recurrence occurred after 28 days of follow-up. No toxic or side effects occurred after treatment. The results showed that the combination of artemether in the treatment of falciparum falciparum has the advantages of quick effect, high efficiency and low toxicity. The formation of gametoids seems to inhibit. In the endemic area of drug-resistant falciparum malaria there is an expanded use value.