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近年来随着分子生物学研究的进展,对HBV基因结构及其表达的了解越来越清楚,对e抗原系统认识越来越精细,并更新了过去对e系统某些观念,现将这方面进展综述如下: 一、e抗原的分子结构及与HBcAg的关系1.前C区(pre—C)区的发现已经证明HBV含有四个开读框架,分别称为S、C、X、P编码区。其中C区编码核衣壳蛋白(HBcAg)P22或P_(22)P_(19)多肽。现发现C区含有两个起动编码(AUG)信号,分别位于第1814与1901位。如将第1901位置的AuG作为合成的起动信号,那么可把第1814与1901间区域称为前C区。已经证明了前c区具
In recent years, with the progress of molecular biology research, the understanding of HBV gene structure and its expression is more and more clear, more and more elaborate on e antigen system, and updated some concepts of e system in the past, Progress is summarized as follows: First, the molecular structure of e antigen and the relationship with HBcAg 1. The pre-C region (pre-C) region has been found that HBV contains four open reading frames, respectively, called S, C, X, P encoding Area. The C region encodes nucleocapsid protein (HBcAg) P22 or P 22 P 19 polypeptide. It is now found that the C region contains two start codings (AUG) signals, located at positions 1814 and 1901, respectively. If the 1901 position of the AuG as a synthetic start signal, then the first 1814 and 1901 area can be called the former C area. The first c area has been proved