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[目的]观察当归黄芪饮联合西药治疗难治性高血压疗效。[方法]使用随机平行对照方法,将90例住院及门诊患者按掷骰子方法简单随机分为两组。对照组45例美托洛尔50mg/次,2次/d;贝那普利10mg/次,2次/d;氢氯噻嗪20~50mg/次,1次/d;硝苯地平30~60mg/次,1次/d。治疗组45例当归黄芪饮,玉米须60g,天麻10g,当归、黄芪各10g,1剂/d,水煎服400m L,早晚口服;西药治疗同对照组。连续治疗15d为1疗程。观测临床症状、尿素氨、尿微量蛋白、24h尿蛋白定量、肌酐、血红蛋白、血浆蛋白、不良反应。治疗1疗程(15d),判定疗效。[结果]治疗组痊愈12例,显效23例,有效8例,无效2例,总有效率96.32%;对照组痊愈2例,显效3例,有效7例,无效30例,总有效率33.25%;治疗组疗效优于对照组(P<0.01)。尿素氨、尿微量蛋白、24h尿蛋白定量、肌酐、血红蛋白、血浆蛋白两组均有改善(P<0.05,P<0.01),治疗组改善优于对照组(P<0.05,P<0.01)。[结论]当归黄芪饮联合西药治疗难治性高血压,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Angelica Huangqi Decoction combined with Western medicine on refractory hypertension. [Methods] Using randomized parallel control method, 90 inpatients and outpatients were randomly divided into two groups according to the dice method. In the control group, 45 patients received metoprolol 50 mg twice daily, benazepril 10 mg twice daily, hydrochlorothiazide 20 to 50 mg once daily, nifedipine 30 to 60 mg daily , 1 time / d. The treatment group, 45 cases of Angelica Astragalus drink, 60 grams of corn, Tianma 10g, Angelica, Astragalus 10g, 1 / d, decoction 400m L, sooner or later oral; Western medicine treatment with the control group. Continuous treatment of 15d for a course of treatment. Clinical symptoms, urea ammonia, microalbuminuria, 24h urinary protein, creatinine, hemoglobin, plasma protein and adverse reactions were observed. Treatment of a course of treatment (15d), to determine the efficacy. [Results] The treatment group cured 12 cases, effective in 23 cases, effective in 8 cases, ineffective in 2 cases, the total effective rate was 96.32%; the control group recovered in 2 cases, markedly effective in 3 cases, effective in 7 cases, ineffective in 30 cases, the total effective rate was 33.25% The treatment group was better than the control group (P <0.01). Urea ammonia, urine microalbuminuria, 24h urinary protein, creatinine, hemoglobin and plasma protein were improved in both groups (P <0.05, P <0.01). The treatment group improved better than the control group (P <0.05, P <0.01). [Conclusion] Angelica Huangqi Decoction combined with Western medicine in the treatment of refractory hypertension, satisfactory results, no serious adverse reactions, it is worth promoting.