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目的：评估伽玛刀（γ－刀）手术对垂体腺瘤的治疗效果。方法：对２９２例垂体腺瘤患者，用１．５Ｔ磁共振和γ－ｐｌａｎ计算机联网定位，Ｌｅｋｓｅｌ伽玛刀实施放射外科手术。肿瘤直径３．８～５１．１ｍｍ，平均１６．３ｍｍ，处方剂量９～３５Ｇｙ，平均２１．６Ｇｙ。结果：本组获随访２０４例（１２～３４个月，平均２１个月），肿瘤消失３９例（１９．１％），缩小１５６例（７６．４％）；激素值恢复正常１４例（１１．８％），较术前下降９４例（７９．６％）；临床症状改善１９０例（９３．１％），９例症状加重，３例肿瘤增大，２例开颅手术，１例死亡。结论：γ－刀是治疗垂体腺瘤安全、有效的一种方法，但要严格掌握适应证，对Ⅲ级以上肿瘤应首选手术治疗，γ－刀治疗后有可能加重垂体功能低下或诱发垂体危象。
Objective: To evaluate the therapeutic effect of gamma knife (gamma knife) surgery on pituitary adenomas. METHODS: A total of 292 patients with pituitary adenomas underwent radiosurgery using 1.5T magnetic resonance imaging and gamma-plan computer networking. Leksel gamma knife was used for radiosurgery. The tumor diameter was 3.8 to 51.1 mm with an average of 16.3 mm, and the prescription dose was 9 to 35 Gy with an average of 21.6 Gy. Results: 204 patients were followed up in this group (12-34 months, average 21 months), tumor disappeared in 39 cases (19.1%), 156 cases were reduced (76.4%); hormone value returned to normal in 14 cases (11 .8%), 94 cases (79.6%) lower than before; 190 cases (93.1%) improved clinical symptoms; 9 cases aggravated, 3 cases increased tumor, 2 cases craniotomy, 1 case died. . Conclusion: Gamma-knife is a safe and effective method for the treatment of pituitary adenomas, but it is necessary to strictly grasp the indications. Surgical treatment should be the first choice for tumors above grade III. Gamma-knife treatment may aggravate hypopituitarism or induce pituitary damage. Like.