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目的 探讨慢性阻塞性肺疾病 (COPD)病人缓解期肺功能与动脉血气的关系。方法 用 62 0 0Au toboxDL 体积描记仪和IL 162 0型血气分析仪分别测定缓解期COPD患者肺功能、动脉血气 ,并对肺功能和动脉血气进行相关性检验。结果 PaCO2 与FVC %Pred、FEV1 %Pred、FEV1 FVC %Pred、FEF2 5～ 75 % %Pred、Vmax75 %Pred、Vmax5 0 %Pred、Vmax2 5 %Pred呈非常显著负相关 (P <0 .0 1) ,与FET2 5～ 75 % 、RV %Pred、RV TLC %Pred、FRC %Pred呈非常显著正相关 ( P <0 .0 1) ,与DLCO 各值不相关。PaO2 与FVC %Pred、FEV1 %Pred、FEV1 FVC %Pred、FEF2 5～ 75 % %Pred、Vmax75 %Pred、Vmax5 0 %Pred、Vmax2 5 %Pred呈非常显著正相关 (P <0 .0 1) ,与FET2 5～ 75 % 呈非常显著负相关 (P<0 .0 1) ,与RV TLC %Pred、DLCO%Pred、DLCO VA %Pred、COT .C呈显著正相关 (P <0 .0 5 )。结论 气道阻塞、残气量增加、肺弥散功能障碍等病理生理改变可能是导致COPD缓解期病人低氧血症的重要因素。
Objective To investigate the relationship between pulmonary function and arterial blood gas in patients with chronic obstructive pulmonary disease (COPD) during remission. Methods Pulmonary function and arterial blood gas were measured in 62 COPA patients with IL-200 blood gas analyzer and 62 0 0Au toboxDL plethysmograph. The correlation between pulmonary function and arterial blood gas was tested. Results PaCO2 had a very significant negative correlation with FVC% Pred, FEV1% Pred, FEV1 FVC% Pred, FEF2 5 ~ 75% Pred, Vmax75% Pred, Vmax50% Pred and Vmax2 5% Pred (P < , There was a very significant positive correlation (P <0.01) with FET2 5 ~ 75%, RV% Pred, RV TLC% Pred and FRC% Pred. PaO2 had a significant positive correlation with FVC% Pred, FEV1% Pred, FEV1 FVC% Pred, FEF2 5 ~ 75%% Pred, Vmax75% Pred, Vmax5 0% Pred and Vmax2 5% Pred (P < There was a significant negative correlation (P <0.01) with FET2 5 ~ 75% and a significant positive correlation with RV TLC% Pred, DLCO% Pred, DLCO VA% Pred and COT. . Conclusions Pathological changes such as airway obstruction, increased residual volume and diffuse pulmonary dysfunction may be the important factors leading to hypoxemia in COPD patients.