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目的探讨急性脑梗死合并2型糖尿病患者同型半胱氨酸水平(Hcy)对预后的影响。方法 84例急性脑梗死患者,根据有无2型糖尿病分为糖尿病组(48例)和非糖尿病组(36例),对两组进行72 h动态血糖监测,比较相关指标。比较两组治疗前后中国脑卒中患者临床神经功能缺损评分标准(CSS)评分情况及治疗前Hcy水平差异。结果糖尿病组患者血清Hcy含量为(27.97±13.83)umo1/L,非糖尿病组患者血清Hcy含量为(19.79±8.64)umo1/L,两组患者Hcy含量比较差异有统计学意义(P<0.05)。糖尿病组入院时及入院后14 d CSS评分均显著高于非糖尿病组,差异具统计学意义(P<0.05)。结论急性脑梗死合并2型糖尿病患者血清Hcy含量及CSS评分均明显高非糖尿病组,说明糖尿病组患者预后较差。故针对高血清Hcy含量治疗,可延缓急性脑梗死合并2型糖尿病患者的病程进展。
Objective To investigate the effect of homocysteine (Hcy) on prognosis in patients with acute cerebral infarction and type 2 diabetes. Methods Eighty-four patients with acute cerebral infarction were divided into diabetic group (n = 48) and non-diabetic group (n = 36) according to the presence or absence of type 2 diabetes. The clinical neurological deficit score (CSS) score of Chinese stroke patients before and after treatment and the difference of Hcy level before and after treatment were compared between the two groups. Results Serum Hcy level was (27.97 ± 13.83) umo1 / L in diabetic patients and 19.79 ± 8.64 umo1 / L in non-diabetic patients. There was significant difference in Hcy between two groups (P <0.05) . The CSS scores of the diabetic patients on admission and on the 14th day after admission were significantly higher than those of the non-diabetic patients, with statistical significance (P <0.05). Conclusion Serum Hcy levels and CSS scores in patients with acute cerebral infarction complicated with type 2 diabetes are significantly higher than those in non-diabetic patients, indicating that patients with diabetes mellitus have a poor prognosis. Therefore, for the treatment of high serum Hcy content, can delay the course of disease in patients with acute cerebral infarction complicated with type 2 diabetes.