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骨髓增生异常综合征(Myelodysplastic Syndrome MDS)又称白前综合征,是以骨髓无效造血、成熟障碍、外周血中一系或数系血细胞减少以及形态和功能异常为主要特征的一组血液病。1982年,FAB协作组将MDS分为五型:1)难治性贫血(RA);2)环状铁粒幼细胞性贫血(RSA);3)原始细胞过多性难治性贫血(RAEB);4)慢性粒-单细胞性白血病(CMML);5)转化中的RAEB(RAEB-t)。该分类对统一对MDS的认识有一定的意义,但由于分类主要依据形态学特征,而本综合征的临床表现和病程变化较为复杂,因而尚不能满意地指导临床。近年来,由于造血细胞培养技术的发展,不少学者通过研究MDS患者粒单系祖细胞(CFU-GM)的体外生长,试图进一步了解
Myelodysplastic syndrome (Myelodysplastic Syndrome MDS), also known as pre-white syndrome, is a group of hematological diseases characterized by ineffective bone marrow hematopoiesis, maturation disorders, one or more cytopenias in peripheral blood and morphological and functional abnormalities. In 1982, the FAB collaborative group classified MDS into five types: 1) refractory anemia (RA); 2) ring-shaped cytogenetic erythroblastic anemia (RSA); 3) primordial supranuclear intractable anemia (RAEB ); 4) Chronic granulocytic-monocytic leukemia (CMML); 5) RAEB under transformation (RAEB-t). The classification of the understanding of the unity of the MDS has some significance, but because the classification is based mainly on morphological characteristics, and the clinical manifestations of this syndrome and changes in the course of the more complex and therefore not yet able to guide the clinical satisfaction. In recent years, due to the development of hematopoietic cell culture technology, many scholars try to understand more about the in vitro growth of granulocyte-derived progenitor cells (CFU-GM) in MDS patients