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伏立康唑是一种新型广谱三唑类抗真菌药,为氟康唑衍生物,具有抗菌谱广、抗菌效力强的特点,对念珠菌属具有抗菌作用,对曲霉属真菌有杀菌作用。通过抑制真菌中由细胞色素P450介导的14a-甾醇去甲基化,抑制麦角甾醇的生物合成产生抗真菌作用。中国2011年“念珠菌诊断与治疗专家共识”中推荐伏立康唑用于治疗氟康唑耐药的念珠菌引起的严重侵袭性感染[1]。此外伏立康唑还用于治疗侵袭性曲霉病,足放
Voriconazole is a new broad-spectrum triazole antifungal agent, fluconazole derivatives, with broad antibacterial spectrum, strong antibacterial properties, antibacterial effect on Candida, fungal Aspergillus bactericidal effect. Inhibition of ergosterol biosynthesis by inhibiting demethylation of 14a-sterols in fungi by cytochrome P450 produces antifungal effects. China 2011 “Candida Diagnosis and Treatment Expert Consensus” recommended voriconazole for the treatment of fluconazole-resistant Candida infections caused by severe infections [1]. In addition voriconazole is also used to treat invasive aspergillosis, enough to put