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目的:探讨甘利欣和丹参注射液在治疗慢性乙型肝炎中保肝、降酶、退黄及抗纤维化作用。方法:将116例慢性乙型肝炎患者随机分为治疗组(58例)和对照组(58例),治疗组应用甘利欣联合丹参注射液,对照组应用甘利欣,另加用一般性保肝药物(门冬氨酸钾镁、肌苷),疗程12周,治疗前后检测肝功能,肝纤维化指标,透明质酸(HA),层粘蛋白(LN),Ⅳ型胶原(Ⅳ.c)等变化;结果:甘利欣联合丹参注射液治疗组在血清肝纤维化指标方面下降明显,与对照组差异显著(P<0.05),在肝功能方面也优于对照组,尤其是SB下降,A./G比例上升显著;结论:甘利欣联合丹参注射液在治疗慢性乙型肝炎中有肯定的临床疗效,能显著改善肝功能,降低肝纤维化指标,抑制或减轻肝纤维化的发生。
Objective: To investigate the effect of Glycyrrhizin and Salvia miltiorrhiza injection on hepatoprotective, antihypertensive, anti-yellowing and anti-fibrosis in the treatment of chronic hepatitis B.Methods: Methods: A total of 116 patients with chronic hepatitis B were randomly divided into treatment group (58 cases) and control group (58 cases). The treatment group was treated with Ganlixin combined with Salvia miltiorrhiza injection. The control group was treated with Ganlixin, Drugs (potassium magnesium aspartate, inosine) for 12 weeks, liver function, liver fibrosis index, hyaluronic acid (HA), laminin (LN) (P <0.05), and also better than the control group in liver function, especially SB decreased, A .Conclusion: Salvia miltiorrhiza combined with Salvia miltiorrhiza injection in the treatment of chronic hepatitis B have a certain clinical efficacy, can significantly improve liver function, reduce liver fibrosis indicators, inhibit or reduce the occurrence of liver fibrosis.