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蛋白结合对药代动力学的影响 药物与蛋白结合会影响药物的分布和消除,因而影响其作用的强度和时间。 表1为四环素类蛋白结合率与药代动力学间的关系(37)。 心甙也是一个明显的例子,洋地黄毒
The effect of protein binding on pharmacokinetics Drug-protein binding affects the distribution and elimination of drugs, thus affecting the intensity and duration of their effects. Table 1 shows the relationship between tetracycline protein binding rate and pharmacokinetics (37). An obvious example of glycosides is digoxin