论文部分内容阅读
目的:探讨血清瘦素水平与冠状动脉病变程度的关系。方法:用放射免疫法检测冠状动脉造影确诊的冠心病患者101例(男59例,女42例)及与其年龄,性别及体质指数相匹配的健康体检者96例(男50例,女46例)的血清瘦素水平。用改良的Gensini评分系统对冠状动脉病变程度进行评分。结果:冠心病组无论男女,血清瘦素水平均显著高于对照组[(8.43±4.29)∶(4.34±2.15)μg/L、(15.87±8.07)∶(8.36±3.81)μg/L](P<0.01)。随着冠状动脉病变程度的加重,冠心病患者血清瘦素水平逐渐升高。Gensini积分为11的患者与积分为5的患者之间血清瘦素水平差异有统计学意义[(12.90±0.92)∶(8.44±0.57)μg/L,P<0.05]。结论:冠心病患者的血清瘦素水平明显高于健康者,并随着冠脉病变程度的增加而升高。
Objective: To investigate the relationship between serum leptin level and severity of coronary artery disease. Methods: Ninety-one patients (59 males and 42 females) with coronary heart disease diagnosed by coronary angiography and 96 healthy subjects (50 males and 46 females) matched with their age, sex and body mass index ) Serum leptin levels. Coronary artery lesions were scored using a modified Gensini scoring system. Results: The levels of serum leptin in CHD group were significantly higher than those in control group [(8.43 ± 4.29) vs (4.34 ± 2.15) μg / L, (15.87 ± 8.07) vs (8.36 ± 3.81) μg / L] P <0.01). With the severity of coronary artery disease, serum leptin levels in patients with coronary heart disease gradually increased. Serum leptin levels were significantly different between patients with a Gensini score of 11 and those with a score of 5 [(12.90 ± 0.92) vs (8.44 ± 0.57) μg / L, P <0.05). Conclusion: Serum leptin levels in patients with coronary heart disease were significantly higher than those in healthy subjects and increased with the degree of coronary artery disease.