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目的比较奥曲肽与法莫替丁治疗急性胰腺炎的临床疗效。方法选取宾阳县人民医院2013年2月—2015年11月收治的急性胰腺炎患者67例,根据治疗方式的不同分为对照组33例和观察组34例。对照组患者给予法莫替丁注射液治疗,观察组患者给予奥曲肽治疗,两组患者均持续治疗2个疗程,并均给予心理干预。比较两组患者的临床疗效、临床指标(腹痛缓解时间、血淀粉酶恢复正常时间、尿淀粉酶恢复正常时间、进食恢复时间、住院时间)、不良反应发生情况及治疗满意度。结果观察组患者临床疗效优于对照组(P<0.05)。观察组患者腹痛缓解时间、血淀粉酶恢复正常时间、尿淀粉酶恢复正常时间、进食恢复时间、住院时间均短于对照组(P<0.05)。观察组患者不良反应发生率低于对照组(P<0.05)。随访6个月,观察组患者疾病复发率低于对照组(P<0.05)。观察组患者治疗满意度优于对照组(P<0.05)。结论奥曲肽治疗急性胰腺炎临床疗效优于法莫替丁,可快速改善患者临床症状及体征,提高患者治疗依从性,且安全可靠。
Objective To compare the clinical efficacy of octreotide and famotidine in the treatment of acute pancreatitis. Methods Sixty-seven patients with acute pancreatitis admitted by Binyang People’s Hospital from February 2013 to November 2015 were divided into control group (n = 33) and observation group (n = 34) according to the different treatment methods. Patients in the control group were treated with famotidine injection, while patients in the observation group were given octreotide. Both groups were treated with 2 courses of continuous therapy and were given psychological intervention. The clinical efficacy, clinical indicators (pain relief time, blood amylase recovery time, urine amylase recovery time, feeding recovery time, hospital stay), adverse reactions and treatment satisfaction were compared between the two groups. Results The clinical efficacy of the observation group was better than that of the control group (P <0.05). Abdominal pain relief time, blood amylase recovery time, urinary amylase recovery time, diet recovery time and hospital stay in observation group were shorter than those in control group (P <0.05). The incidence of adverse reactions in observation group was lower than that in control group (P <0.05). Follow-up 6 months, the observation group patients with disease recurrence rate was lower than the control group (P <0.05). Patients in the observation group had better treatment satisfaction than those in the control group (P <0.05). Conclusion The clinical efficacy of octreotide in the treatment of acute pancreatitis is better than that of famotidine, which can rapidly improve the clinical symptoms and signs of patients and improve the compliance of patients with the treatment and is safe and reliable.