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目的了解云南省新平县傣族儿童地中海贫血和G6PD缺乏症的现状。方法地中海贫血检测:对调查者用日本特康血细胞分析仪进行血细胞分析,PH8.6缓冲液醋酸纤维薄膜做电泳分析;G6PD缺乏症检测:采用改良葡萄糖6-磷酸脱氢酶(G6PD)测定比值法(手工操作法)进行检测。结果β一地贫检出率6.5%,α-地贫检出率8.7%,G6PD缺乏症检出率8.3%。结论地贫和G6PD缺乏症在云南省新平县傣族儿童中属高发,地贫和G6PD缺乏症的人群地理分布与历史上疟疾流行的地理分布存在着一定的相关性。该调查为云南省新平县傣族进行遗传咨询及进行地贫和G6PD缺乏症的预防提供了有价值的基础资料。
Objective To understand the status of thalassemia and G6PD deficiency in Dai children in Xinping County, Yunnan Province. Methods Thalassemia detection: The investigators performed hematocrit analysis with Japanese Tehnology hematology analyzer, electrophoresis analysis with PH8.6 buffer acetate film; G6PD deficiency test: The ratio of glucose 6-phosphate dehydrogenase (G6PD) Law (manual method) for testing. Results The detection rate of β-thalassemia was 6.5%, the detection rate of α-thalassemia was 8.7%, and the detection rate of G6PD deficiency was 8.3%. Conclusions Thalassemia and G6PD deficiency are high prevalence among Dai children in Xinping County, Yunnan Province. The geographical distribution of thalassemia and G6PD deficiency is related to the geographical distribution of malaria in history. The survey provided valuable basic information for genetic counseling and the prevention of thalassemia and G6PD deficiency in the Dai people in Xinping County, Yunnan Province.