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目的 探讨应用小剂量干扰素(IFN)联合阿昔洛韦(Acyclovir)、单用IFN、一般护肝治疗药物三种方法治疗慢性乙肝的疗效。方法 将选择的84例病人随机分为三组,联合组32例应用IFNlmu+Acyclovir0.75;单用组21例,应用IFN 3mu;护肝组31例,应用肝炎灵针4ml;疗程均为3个月。观察临床,ALT和病毒复制指标变化。结果 三组均能减轻或消除肝炎症状,改善肝功,ALT腹常率在治疗后2个月无明显差异。疗程结束后近期观察3个月,其HbeAg、HBVDNA阴转率及复发率,在联合组分别为46.2％、45.2％、6.7％,单用组分别为22.2％、28.6％、11.7％,护肝组分别为3.8％、3.2％、25.9％,有显著差异。结论 小剂量干扰素联合阿昔洛韦治疗慢性乙肝具有与常规剂量干扰素同等的治疗效果,且副作用轻,治疗费用低。
Objective To investigate the curative effect of three kinds of methods of using small dose of interferon (IFN) combined with acyclovir (Acyclovir), IFN alone, and general hepatoprotective therapy on chronic hepatitis B patients. Methods Eighty-four selected patients were randomly divided into three groups. In the combined group, IFNlmu + Acyclovir0.75 was used in 32 cases. In the single group, IFN3mu was used in 31 cases. Liver protection group was used in 31 cases. Hepatitis A needle was used in 4 cases. The course of treatment was 3 Months. Clinical, ALT and viral replication indicators were observed. Results All the three groups could relieve or eliminate the symptoms of hepatitis and improve the liver function. There was no significant difference in ALT rate at 2 months after treatment. During the recent 3 months after the course of treatment, the HbeAg and HBVDNA negative conversion rates and recurrence rates were 46.2%, 45.2% and 6.7% in the combined group and 22.2%, 28.6% and 11.7% in the combined group, respectively Group were 3.8%, 3.2%, 25.9%, there are significant differences. Conclusion Low-dose interferon combined with acyclovir in the treatment of chronic hepatitis B has the same therapeutic effect as conventional dose of interferon, with light side effects and low cost of treatment.