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目的探讨细胞学联合肿瘤标志物鉴别良、恶性胸腔积液的临床价值。方法选取我院2012年3月~2014年2月150例诊断为胸腔积液的患者实施胸腔细胞检测,采用化学荧光法分别检测CEA、CA-50、CA19-9水平,分析标志物临床应用价值。结果恶性胸腔积液中肿瘤标志物含量明显高于良性胸腔积液患者,CEA+CA-50+CA19-9联合应用相比较单一标志物具有更高准确性。结论 CEA+CA-50+CA19-9在良、恶性胸腔积液检测中具有较为明显的应用价值,对于提高癌症诊断准确性具有明显作用。
Objective To investigate the clinical value of cytology combined with tumor markers in differentiating benign and malignant pleural effusions. Methods 150 cases of pleural effusion in our hospital from March 2012 to February 2014 were enrolled in the thoracic cell test. The levels of CEA, CA-50 and CA19-9 were detected by chemiluminescence method, and the clinical value of the markers was analyzed . Results The content of tumor markers in malignant pleural effusion was significantly higher than that in patients with benign pleural effusion. The combined application of CEA + CA-50 + CA19-9 was more accurate than single marker. Conclusion CEA + CA-50 + CA19-9 has obvious application value in the detection of benign and malignant pleural effusion, and has obvious effect on improving the accuracy of cancer diagnosis.