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据推测,目前在日本 HBV 携带者有200～300万人,其中,约10%为慢性肝炎、肝硬化及肝细胞癌等肝病患者,其余90%为无症状HBs 抗原携带者(AsC)。据有价值的流行病学资料表明,包括母婴感染的婴幼儿期感染,在HBV 携带者的成因方面最为重要。最近,在日本正在大规模地探讨着有关预防感染的对策。HBV 携带者的自然经过一般认为,由包括母婴感染的婴幼儿期感染形成的 HBV 携带者,引起肝损害的机会有3次。即感染形成时、HBe 抗原进入人体 HBe 抗体形成前后、HBV 从体内被清除时。因 HBV携带者的肝损害而引起临床症状者,为第二种
Presumably, there are 20-30 million HBV carriers in Japan at present, of which about 10% are liver diseases such as chronic hepatitis, cirrhosis and hepatocellular carcinoma, and the remaining 90% are asymptomatic HBs antigen carriers (AsC). Valuable epidemiological data indicate that infant-to-infant infections, including maternal-fetal infections, are most important in the genesis of HBV carriers. Recently, Japan is exploring a large-scale countermeasure to prevent infection. Naturalization of HBV carriers It is generally believed that there are three chances of liver damage caused by HBV carriers formed during infancy, including mother-infant infection. That infection is formed, HBe antigen into the body before and after the formation of HBe antibodies, HBV is cleared from the body. For HBV carriers who cause liver damage caused by clinical symptoms, for the second