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目的探讨淋巴细胞主动免疫治疗不明原因反复流产?URSA?的疗效。方法对175例不明原因的反复流产,封闭抗体缺乏,自身抗体阴性的患者运用配偶或第三方淋巴细胞皮内注射法治疗,以治疗前后封闭抗体为指标,观察细胞免疫功能的变化,封闭抗体转阳性后指导安排受孕,孕后联合孕酮及中药保胎。结果临床妊娠98例,妊娠成功89例,再次流产8例,异位妊娠1例,妊娠成功率91.75%。结论对于URSA患者,淋巴细胞主动免疫治疗疗效显著,安全可靠。
Objective To investigate the efficacy of active immunotherapy of lymphocytes with unexplained recurrent spontaneous abortion (URSA). Methods 175 cases of unexplained repeated abortion, lack of blocking antibodies, autoantibodies negative patients using spleen or third party intradermal injection of lymphocytes treatment, before and after treatment with closed antibody as an indicator to observe the changes in cellular immune function, blocking antibody turnover After the positive guidance arrangement pregnancy, pregnancy combined with progesterone and Chinese miscarriage. Results Clinical pregnancy in 98 cases, 89 cases of pregnancy success, abortion again in 8 cases, 1 case of ectopic pregnancy, pregnancy success rate of 91.75%. Conclusion For patients with URSA, active immunotherapy of lymphocytes is significant, safe and reliable.