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目的:分析肝癌组织之中血管内皮生长因子(VEGF)、淋巴管内皮的透明质酸受体(LYVE-1)在表达水平以及临床的意义。方法:选择在粤北第二人民医院治疗的肝癌患者66例,全部患者均使用免疫组织的化学法进行检测,观察比较VEGF、LYVE-1在不同肝癌组织中的表达水平及意义。结果:在肝癌的组织中,VEGF表达明显比正常的组织高,差异具有统计学意义(P<0.05);在肝癌组织以及癌旁组织中,LYVE-1阳性率明显比正常的肝组织高,差异具有统计学意义(P<0.05);在肝癌组织、肝癌旁组织患者、正常肝脏的组织中,VEGF与LYVE-1阳性率对比后,差异具有统计学意义(P<0.05)。结论:肝癌组织中VEGF、LYVE-1表达有重要的意义。
Objective: To analyze the expression of vascular endothelial growth factor (VEGF) and lytic vessel endothelium hyaluronan receptor (LYVE-1) in hepatocellular carcinoma and its clinical significance. Methods: Sixty-six patients with hepatocellular carcinoma (HCC) treated in the Second People’s Hospital of Guangdong Province were enrolled. All the patients were detected by immunohistochemistry. The expression and significance of VEGF and LYVE-1 in different HCC tissues were observed and compared. Results: The expression of VEGF in HCC tissues was significantly higher than that in normal tissues (P <0.05). The positive rate of LYVE-1 in HCC tissues and paracancer tissues was significantly higher than that in normal liver tissues, (P <0.05). There was significant difference between the positive rate of VEGF and LYVE-1 in the tissues of HCC, paracancer tissues and normal liver tissue (P <0.05). Conclusion: The expression of VEGF and LYVE-1 in hepatocellular carcinoma has important significance.