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评价百日咳免疫接种的效果是有困难的,从而围绕其安全性和效果问题发生了争论,并导致70年代百日咳免疫接种的接受率(指4岁以下的儿童接受全程基础免疫的比率)显著下降。1978年英国全国性百日咳大流行,提供了对一群住院百日咳患儿进行研究的机会,旨在观察因病情严重而住院的患儿是否接种过百日咳菌苗。
Assessing the efficacy of immunization against whooping cough has been problematic, controversy surrounding its safety and efficacy issues, and led to a marked decline in the rate of immunization against whooping cough in the 1970s (the percentage of children under the age of 4 undergoing basic immunization). The 1978 British National Pertussis Pandemic provided an opportunity to study a group of children with in-hospital pertussis to see whether children who were hospitalized for serious conditions had been vaccinated against pertussis.