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目的：研究流行性乙型脑炎（乙脑）的发病与内源性阿片多肽的关系，以及纳洛酮治疗的效果观察。方法：将３６例乙脑患者分为对照组和治疗组。收集治疗组纳洛酮治疗前极期和治疗后恢复期的血和脑脊液（ＣＳＦ）标本，用活性炭吸附放免法检测其中内源性阿片多肽的含量，并与正常人比较，结果用ｔ、ｔ′检验和配对ｔ检验处理。结果：乙脑极期血浆强啡肽含量显著增高，明显超过正常人（Ｐ＜０．０１）；而恢复期含量比极期明显下降（Ｐ＜０．００１）。乙脑极期ＣＳＦ中亮氨酸脑啡肽、β内啡肽和强啡肽含量比正常人明显升高（Ｐ＜０．０１），恢复期含量比极期明显下降（Ｐ＜０．００１）。纳洛酮治疗组在退热、抽搐停止、神志转清和脑膜刺激征改善时间上均较对照组明显缩短（Ｐ＜０．０１）。结论：乙脑的发病与内源性阿片多肽释放增加有关。纳洛酮是治疗乙脑的有效药物。
Objective: To study the relationship between the incidence of Japanese encephalitis (JE) and endogenous opioid peptides and the effect of naloxone treatment. Methods: 36 cases of JE patients were divided into control group and treatment group. The blood and cerebrospinal fluid (CSF) samples of naloxone in the treatment group before and after convalescence were collected. The contents of endogenous opioid peptides in the treatment group were detected by radioimmunoassay and radioimmunoassay and compared with normal subjects. The results were expressed as t, t ’Test and paired t test. Results: The content of dynorphin in the plasma of JE increased significantly (P <0.01), but decreased significantly in the recovery phase (P <0.001). The content of leucine-enkephalin, β-endorphin and dynorphin in the cerebrospinal fluid (CSF) of JE increased significantly (P <0.01) and the content of recovery phase decreased significantly (P <0) .001). Naloxone treatment group in the antipyretic, convulsions stopped, consciousness clear and meningeal irritation time to improve compared with the control group was significantly shorter (P <0.01). Conclusion: The incidence of Japanese encephalitis is related to the increased release of endogenous opioid peptides. Naloxone is an effective drug for treating JE.