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目的:研究自制中药方剂浸泡四肢末端对减弱奥沙利铂诱发神经毒性的疗效观察。方法:将79例使用含奥沙利铂化疗方案的肿瘤患者,随机分为对照组和中药组,分别用安慰剂(40℃温水)和自制中药方(40℃)浸泡四肢末端,观察、比较两组的疗效。结果:中药组肿瘤患者神经毒性发生率、分级均低于对照组,具有统计学意义。结论:自制外用中药方能有效减弱奥沙利铂所致的神经毒性。
OBJECTIVE: To study the curative effect of self-made traditional Chinese medicine soaking extremities on reducing the neurotoxicity induced by oxaliplatin. Methods: Totally 79 patients with oxaliplatin-containing chemotherapy were randomly divided into the control group and the traditional Chinese medicine group. The extremities of the extremities were immersed in placebo (40 ℃ warm water) and self-made Chinese herbal medicine (40 ℃) respectively, and observed and compared The two groups of curative effect. Results: The incidence and grade of neurotoxicity in tumor patients in TCM group were lower than those in control group, with statistical significance. Conclusion: Self-made topical Chinese herbs can effectively reduce the neurotoxicity caused by oxaliplatin.