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目的:研究分析早产儿患感染性疾病与脑损伤发生的相关程度。方法:随机抽取250例早产儿的临床资料,患有感染性疾病162例,分析脑损伤的基本情况,根据有无脑损伤进行分组,对比测量两组早产儿血清降钙素原(PCT)、C反应蛋白(CRP)水平,正向和反向研究感染性疾病导致脑损伤的相关性和危险因素。结果:感染性疾病早产儿中54例(33.2%)有脑损伤情况。所有69例脑损伤早产儿中感染指标超标占77.78%(54/69),明显高于无脑损伤组。轻度感染脑损伤发生率显著低于重度感染患儿脑损伤发生率,差异显著存在统计学意义(χ2=11.18,P<0.05)。结论:早产儿患感染性疾病可损害神经系统组织和功能,在重度感染和多因素情况下脑损伤程度更重。
Objective: To study and analyze the correlation between infectious diseases in preterm infants and the occurrence of brain injury. Methods: The clinical data of 250 premature infants were randomly selected and 162 cases were infected with infectious diseases. The basic situation of brain injury was analyzed. The brain injury was divided into groups. The serum procalcitonin (PCT) C-reactive protein (CRP) levels in both positive and negative studies of the relevance and risk factors for infectious disease-induced brain injury. Results: 54 cases (33.2%) of premature infants with infectious diseases had brain injury. In all 69 cases of premature infants with brain injury, the infection index exceeded 77.78% (54/69), which was significantly higher than those without brain injury. The incidence of mildly infected brain injury was significantly lower than that of severe infection in children with brain injury, the difference was statistically significant (χ2 = 11.18, P <0.05). CONCLUSIONS: Infectious diseases in preterm infants can impair nervous system tissue and function, with a greater degree of brain damage following severe infections and multiple factors.