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目的调查中国湖北汉族人群ＨＬＡ－Ⅱ类基因频率。方法用聚合酶链反应／序列特异性引物和聚合酶链反应／限制性片段长度多态性技术，对中国湖北汉族１６８名正常个体进行了ＨＬＡ－ＤＲＢ１（ｎ＝１６８）、ＨＬＡ－ＤＱＢ１（ｎ＝１６０）、ＨＬＡ－ＤＰＢ１（ｎ＝９３）基因的多态性检测。结果共检出３９种ＤＲＢ１、１５种ＤＱＢ１和１７种ＤＰＢ１等位基因型别，等位基因频率较高的分别是：ＤＲＢ１＊０９０１（ｇｅｎｅｆｒｅｑｕｅｎｃｙ，ＧＦ＝１４％）、＊１５０１（ＧＦ＝１１．３％）、＊０３０１（ＧＦ＝７．１％）、＊０８０３（ＧＦ＝４．８％）等；ＤＱＢ１＊０３０１（ＧＦ＝１８．８％）、＊０３０３（ＧＦ＝１８．４％）、＊０２０１（ＧＦ＝１０％）、＊０３０２（ＧＦ＝８．４％）等；ＤＰＢ１＊０５０１（ＧＦ＝３１．２％）、＊０４０１（ＧＦ＝１５．１％）、＊０２０１（ＧＦ＝１４％）、＊０４０２（ＧＦ＝１１．８％）等。与白种人群相比，中国湖北汉族的ＤＲＢ１＊０９０１、１００１、０８０３；ＤＱＢ１＊０３０３、０５０２；ＤＰＢ１＊０５０１、０２０２等频率明显升高，而ＤＲＢ１＊０３０１、０４０１、１３０１；ＤＱＢ１＊０２０１、０６０３；ＤＰＢ１＊０４０１?
Objective To investigate the frequency of HLA-Ⅱ genotypes in Chinese Han population in Hubei Province, China. Methods A total of 168 normal individuals from Han nationality in Hubei province of China were genotyped by HLA-DRB1 (n = 168), HLA-DQB1 (n = 160), polymorphism of HLA-DPB1 (n = 93). Results A total of 39 DRB1, 15 DQB1 and 17 DPB1 alleles were detected. The higher allele frequency was DRB1 * 0901 (GF = 14%) and * 1501 (GF = 11). DQB1 * 0301 (GF = 18.8%), * 0303 (GF = 18.4%), * 0301 * 0201 (GF = 10%), * 0302 (GF = 8.4%) and the like; DPB1 * 0501 (GF = 31.2%), * 0401 (GF = 15.1%), %), * 0402 (GF = 11.8%) and the like. Compared with the white population, the frequency of DRB1 * 0901, 1001, 0803, DQB1 * 0303, 0502 and DPB1 * 0501,0202 in Han nationality in Hubei Province of China were significantly increased, while the frequencies of DRB1 * 0301,0401,1301, DQB1 * 0201,0603 ; DPB1 * 0401?