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目的观察胃铋镁颗粒联合雷贝拉唑、阿莫西林、克拉霉素对维吾尔族患者幽门螺杆菌(Hp)根除治疗的效果。方法选择2015年2~7月喀什地区第二人民医院经~(14)C-尿素呼气试验确诊的78例Hp感染的维吾尔族患者为研究对象,将其随机分为治疗组和对照组,各39例。治疗组给予胃铋镁四联疗法(胃铋镁颗粒、雷贝拉唑、阿莫西林、克拉霉素)14 d后,继续口服胃铋镁颗粒、雷贝拉唑14 d;对照组给予标准三联疗法(雷贝拉唑、阿莫西林、克拉霉素)14 d后,再继续口服雷贝拉唑14 d。疗程结束停药1个月后复查~(14)C-尿素呼气试验。比较两组患者Hp根除率、消化道症状改善及不良反应发生情况。结果治疗组Hp根除率(94.9%,37/39)明显高于对照组(79.5%,31/39),差异有统计学意义(P<0.05)。两组患者的消化道症状均有改善,其中治疗组症状治愈率(97.4%,38/39)明显高于对照组(79.5%,31/39),差异有统计学意义(P<0.05)。治疗组和对照组不良反应发生率分别为0.0%、12.8%(5/39),差异无统计学意义(P>0.05)。结论胃铋镁四联疗法在临床上对维吾尔族患者Hp根除、解除消化道症状效果优于标准三联疗法,值得在少数民族地区推广应用。
Objective To observe the effect of gastric bismuth magnesium granules combined with rabeprazole, amoxicillin and clarithromycin in the eradication therapy of Helicobacter pylori (Hp) in Uygur patients. Methods A total of 78 Hp-infected Uyghur patients diagnosed by ~ (14) C-urea breath test in Second People’s Hospital of Kashi Prefecture from February to July 2015 were selected as study subjects and randomly divided into treatment group and control group, 39 cases each. The treatment group was treated with gastric bismuth magnesium quadruple therapy (Bismuth Magnesium Granules, Rabeprazole, Amoxicillin, Clarithromycin) for 14 days and then continued oral administration of magnesium bismuth particles and rabeprazole for 14 days. The control group was given standard Triple therapy (rabeprazole, amoxicillin, clarithromycin) 14 d, and then continue oral rabeprazole 14 d. End of treatment after 1 month review ~ (14) C-urea breath test. Hp eradication rate, improvement of gastrointestinal symptoms and adverse reactions were compared between the two groups. Results Hp eradication rate (94.9%, 37/39) in the treatment group was significantly higher than that in the control group (79.5%, 31/39), the difference was statistically significant (P <0.05). The gastrointestinal symptoms of both groups were improved. The cure rate of symptoms in the treatment group (97.4%, 38/39) was significantly higher than that in the control group (79.5%, 31/39), the difference was statistically significant (P <0.05). The incidence of adverse reactions in the treatment group and control group were 0.0% and 12.8% (5/39) respectively, with no significant difference (P> 0.05). Conclusions Stomach bismuth magnesium quadruple therapy in clinical Uighur patients Hp eradication, relieve gastrointestinal symptoms better than the standard triple therapy, it is worth in the minority areas to promote the use of.