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小鼠胚胎、新生和成年小鼠肝脏,都含有一种在体外能抑制小鼠淋巴细胞增生的因子。此因子无品系特异性,能抑制H-2单型相同或不同的淋巴结或脾细胞对植物血凝素(PHA)、刀豆素A(ConA)、大肠杆菌脂多糖(LPS)和混合淋巴细胞培养诱发的淋巴细胞增生。这表明肝脏抑制因子既能抑制T细胞又能抑制B细胞对促有丝分裂原和同种异型抗原刺激所致的应答反应。此因子的抑制作用强烈,在使用浓度时,这种抑制作用是可逆的,一旦洗去肝浸液,淋巴细胞就恢复正常的应答功能。 在肾脏未观察到抑制淋巴细胞增生因子,而脾脏含有比肝脏较弱的抑制因子。
Mouse embryos, newborn and adult mouse livers all contain a factor that inhibits lymphocyte proliferation in mice in vitro. This factor has no strain specificity and can inhibit PHA, ConA, E. coli lipopolysaccharide (LPS) and mixed lymphocytes in lymph nodes or spleen cells with the same or different H-2 haplotypes. Culture-induced lymphocyte proliferation. This indicates that the hepatic inhibitory factor can both suppress T cells and inhibit the response of B cells to mitogen and allotypic antigen stimulation. The inhibitory effect of this factor is strong, and this inhibition is reversible when the concentration is used. Once the liver infusion is washed away, the lymphocytes return to their normal response function. No inhibition of lymphoproliferative factors was observed in the kidney, whereas the spleen contained weaker inhibitory factors than the liver.