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应用小鼠骨髓嗜多染红细胞微核试验，观察了中药肝宁的遗传毒性及肝宁对诱变剂丝裂霉素Ｃ（ＭＭＣ）致遗传损伤的保护作用。结果表明，肝宁对小鼠骨髓微核无诱导作用，但却明显降低丝裂霉素Ｃ诱发的微核率，提示肝宁有明显的抗诱变作用。
The micronucleus test of mouse bone marrow polychromatic erythrocytes was used to observe the genotoxicity of Gan Ning and the protective effect of Gan Ning on the genetic damage induced by mitomycin C (MMC). The results showed that Gan Ning had no effect on the micronuclei of mouse bone marrow, but significantly reduced the micronucleus rate induced by mitomycin C, suggesting that Ganning had a significant anti-mutagenic effect.