论文部分内容阅读
目的 研究膀胱癌染色体数目畸变与预后的关系。方法 对 6 0例膀胱癌肿瘤采用直接法和短期培养法进行染色体标本制备 ,成功 34例 (5 6 .7% ) ,行核型分析并随访 2 2～ 46个月 (平均 32个月 )。结果 随着病理分级、临床分期的增加 ,癌细胞染色体二倍体率下降 ,非二倍体率增加 ,复发和死亡组染色体倍体水平以 3n、4n多见。结论 膀胱癌染色体数目畸变与预后密切相关 ,非二倍体癌易复发 ,恶性程度高。
Objective To study the relationship between chromosome aberration and prognosis in bladder cancer. Methods Chromosome specimens were prepared by direct method and short-term culture method in 60 cases of bladder cancer. 34 cases (56.7%) were successfully performed. The karyotypes were followed up for 2 ~ 46 months (average 32 months). Results With the increase of pathological grade and clinical staging, the rate of chromosome diploid decreased and the rate of non-diploid increased. The level of chromosome ploidy in recurrence and death was more common at 3n and 4n. Conclusion The number of chromosomal aberrations in bladder cancer is closely related to prognosis. Non-diploid cancer is easy to relapse and has a high degree of malignancy.