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目的 观察刮术治疗对泌尿生殖系尖锐湿疣( C A) 的疗效、刮术深度与 C A 复发和瘢痕形成的关系,以及刮术后外周血单核细胞( P B M C) 人类乳头瘤病毒( H P V) 感染的可能性。方法 对230例泌尿生殖系 C A 刮术治疗,并对部分疣组织病理观察,用聚合酶链反应( P C R) 检测术后≤1 周及≥2周以上病例的 P M B C H P V D N A。结果 (1) 、225 例患者皮损1 次治愈,5 例2 次治愈。半年内复发率为6 .9 % ,尿道口内最高(10 % ) 。(2) 、3 例真皮浅层上残留的表皮内有凹空细胞者皮损均在半年内复发。(3) 、19 例刮术后≤1 周 P B M C 检测到 H P V D N A,2 周后均转为阴性。结论 (1) 刮术治疗各部位皮损均较适用;(2) 刮术治愈率及复发率与刮除深度有关;(3) P B M C 含 H P V D N A,可呈一过性。
Objective To observe the curative effect of curettage on genitourinary condyloma acuminatum (CA), the relationship between depth of curettage and recurrence of C A and scar formation, and the relationship between peripheral blood mononuclear cells (PBMC) human papillomavirus (H P V) infection. Methods 230 cases of urogenital C A curettage, and some of the wart histopathological observation, using polymerase chain reaction (P C R) detection of postoperative ≤ 1 week and ≥ 2 weeks of cases of P M B C H P V D N A. Results (1), 225 cases of skin lesions were cured 1, 5 cases were cured 2 times. The recurrence rate in 6 months is 6. 9%, the highest urethra (10%). (2), 3 cases of residual dermal epidermis with concave empty cell lesions were recurrence within six months. (3), 19 cases of Hp V D N A detected by P B M C after ≤ 1 week of curettage, and turned negative after 2 weeks. Conclusion (1) curettage in various parts of the skin lesions are more applicable; (2) curettage cure rate and recurrence rate and curettage depth; (3) P B M C with H P V D N A can be a Passive.