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目的 研究癫痫患儿口服卡马西平的药代动力学，并比较肥胖癫痫患儿与正常体重癫痫患儿的代谢情况。方法 对１５ 例癫痫患儿进行口服卡马西平药代动力学参数测定，按体重分组比较肥胖患儿与正常体重患儿的药物消除特点，其血药浓度采用高效液相色谱法测定。结果 １５ 例患儿口服卡马西平药动学参数为表观分布容积（１－４３ ±０－４５）Ｌ／ｋｇ，消除半衰期（２１－２５ ±１０－０９）ｈ，清除率（５１－７２ ±２０－３０）ｍｌ／（ｋｇ·ｈ）。肥胖患儿比正常体重患儿的药物消除半衰期延长，清除率降低。结论 肥胖患儿卡马西平代谢速率慢于正常体重患儿。
Objective To study the pharmacokinetics of oral carbamazepine in children with epilepsy and to compare the metabolic status of children with obese epilepsy and normal weight epilepsy. Methods The pharmacokinetic parameters of oral carbamazepine were determined in 15 children with epilepsy. The drug elimination characteristics of obese children and normal weight children were compared by body weight, and the plasma concentration was determined by high performance liquid chromatography. Results The kinetic parameters of oral carbamazepine in 15 children were apparent distribution volume (1-43 ± 0-45) L / kg, elimination half-life (21-25 ± 10-09) h, clearance rate (51-72 ± 20-30) ml / (kg · h). Children with obesity than normal weight children with drug elimination half-life extension, reduced clearance. Conclusion The metabolic rate of carbamazepine in obese children is slower than that of normal weight children.