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目的探讨福辛普利联合普伐他汀治疗慢性心力衰竭(CHF)患者的疗效情况。方法选取2015年11月—2016年11月在广州市花都区第二人民医院住院的80例CHF患者,随机分为对照组和观察组,每组40例。对照组在常规治疗的基础上给予福辛普利,观察组在对照组的基础上加用普伐他汀治疗,两组疗程均为8周。比较两组患者治疗前后左心室射血分数(LVEF)、左室舒张末内径(LVEDD)、左室收缩末内径(LVESD)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血清白介素-4(IL-4)、血清白介素-6(IL-6)和肿瘤坏死因子α(TNF-α)等指标,疗程均为8周。结果治疗前,两组LVEF、LVEDD、LVESD、TC、TG、HDL-C、LDL-C、IL-4、IL-6和TNF-α等指标比较,差异无统计学意义(P>0.05)。治疗后,观察组LVEDD和LVESD等指标均低于对照组,LVEF高于对照组,差异均有统计学意义(P<0.05);观察组TC、TG、LDL-C等指标均低于对照组,HDL-C高于对照组,差异均有统计学意义(P<0.05);观察组IL-6和TNF-α均低于对照组,IL-4高于对照组,差异均有统计学意义(P<0.05)。结论福辛普利联合普伐他汀治疗CHF患者疗效较单用福辛普利好。
Objective To investigate the curative effect of fosinopril and pravastatin in patients with chronic heart failure (CHF). Methods Eighty CHF patients hospitalized in Second People’s Hospital of Huadu District, Guangzhou from November 2015 to November 2016 were randomly divided into control group and observation group, 40 cases in each group. The control group was given fosinopril on the basis of routine treatment. The observation group was treated with pravastatin on the basis of the control group, and the two courses of treatment were 8 weeks. The left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein cholesterol (LDL-C), serum interleukin-4 (IL-4), serum interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF- The course of treatment is 8 weeks. Results Before treatment, there was no significant difference in the indexes of LVEF, LVEDD, LVESD, TC, TG, HDL-C, LDL-C, IL-4, IL-6 and TNF- After treatment, the indexes of LVEDD and LVESD in the observation group were lower than those in the control group, and the LVEF was higher in the observation group than in the control group (P <0.05). The indexes of TC, TG and LDL-C in the observation group were lower than those in the control group (P <0.05). The levels of IL-6 and TNF-α in the observation group were lower than those in the control group, while the levels of IL-4 in the observation group were higher than those in the control group, the difference was statistically significant (P <0.05). Conclusion The efficacy of fosinopril combined with pravastatin in CHF patients is better than that of fosinopril alone.