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北美黄连碱在体外试验中(浓度为10μg/ml、20μg/ml、40μg/ml)经过72h,原头节死亡率分别为59.1％66.4％、72.3％,较阿苯达唑、甲苯达唑、吡喹酮为高;扫描电镜观察到原头节多呈外翻型,顶突失去正常构型,头钩脱落,吸盘变形。北美黄连碱治疗小鼠继发性包虫病(3.75mg/kg/day×20,ig),囊肿抑制率达80.5％(P<0.001);扫描电镜观察到棘球蚴生发膜角质层面的微毛断裂脱落,有许多大小不等、深浅不一、边缘不整齐的陷窝,生发膜囊腔面的乳头状突起排列紊乱,出现许多不规则细胞碎片,未见内生性育囊。
In the in vitro experiments (concentration of 10μg / ml, 20μg / ml, 40μg / ml), the mortality of Coptis alkaloids were 59.1%, 66.4% and 72.3% respectively after 72 hours. Compared with albendazole, mebendazole, Praziquantel was high; the scanning electron microscope showed that the protuberance was mostly everted type, the top of the loses normal configuration, the first hook off, the sucker deformation. North American Coptis alkaloid treatment of secondary echinococcosis in mice (3.75mg / kg / day × 20, ig), the cyst inhibitory rate was 80.5% (P <0.001); scanning electron microscopy of echinococcosis hair follicles micro Broken hair off, there are many sizes, different shades, uneven edge of the lacunar, germinal vesicle surface papillary protrusions disorder, there are many irregular cell debris, no endogenous cyst.