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目的:探讨婴幼儿呼吸道合胞病毒性肺炎与血清IgE水平的关系,并探讨婴幼儿呼吸道合胞病毒肺炎喘息与IgE的关系及其与支气管哮喘的相关性。方法:对2009年1月至2010年12月在广州市越秀区儿童医院就诊的76例呼吸道合胞病毒性肺炎婴幼儿进行血清IgE检测,并收集特异性体质的表现及家族史,对有喘息症状的患儿进行随访。结果:呼吸道合胞病毒肺炎患儿血清IgE水平明显高于对照组(P<0.05),呼吸道合胞病毒肺炎喘息组患儿血清IgE水平明显高于无喘息组(P<0.05)。喘息组40例患儿随访中,有25例(62.5%)转为哮喘,其特异性体质表现及家族史与发病密切相关。结论:呼吸道合胞病毒肺炎的发病与血清IgE升高有关,呼吸道合胞病毒肺炎患儿喘息症状及支气管哮喘的发生与血清IgE的水平密切相关,呼吸道合胞病毒感染、血清IgE水平升高是婴幼儿反复发生支气管哮喘的重要危险因素。
Objective: To investigate the relationship between respiratory syncytial virus pneumonia and serum IgE in infants and young children and explore the relationship between respiratory syncytial virus pneumonia and wheezing and IgE in infants and young children and bronchial asthma. Methods: From January 2009 to December 2010 in Guangzhou Yuexiu Children’s Hospital, 76 cases of respiratory syncytial virus pneumonia in infants and young children for serum IgE detection and collection of specific physical manifestations and family history of wheezing Children with symptoms were followed up. Results: The level of serum IgE in children with respiratory syncytial virus pneumonia was significantly higher than that in the control group (P <0.05). The serum level of IgE in children with respiratory syncytial virus pneumonia was significantly higher than that in the non-asthmatic group (P <0.05). In the 40 cases of wheezing group, 25 cases (62.5%) were converted to asthma, and their specific physical manifestation and family history were closely related to the onset of disease. Conclusion: The incidence of respiratory syncytial virus pneumonia is related to the increase of serum IgE. Respiratory syncytial virus pneumonia in children with wheezing symptoms and bronchial asthma is closely related to serum IgE levels. Respiratory syncytial virus infection and serum IgE level are Important infant risk factors for recurrent bronchial asthma.