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目的:探讨卵巢囊性颗粒细胞瘤的临床病理学特征、诊断和鉴别诊断要点。方法:复习1例卵巢囊性颗粒细胞瘤患者的临床资料、肿物的大体以及镜下病理组织学特征、免疫组化染色特征。结果:患者左侧单房囊性颗粒细胞瘤,大小为14.6 cm×18.9 cm×9.8 cm,囊壁厚薄不均一;镜下可见内壁由颗粒细胞组成,细胞层数不一,可见典型的Call-Exner小体;免疫组化染色可见α-inhibin,Vimentin,CD99均阳性。结论:卵巢囊性颗粒细胞瘤可依据镜下发现不典型增生的颗粒细胞、典型的Call-Exner小体和核沟等特征性的组织形态学作出诊断。
Objective: To investigate the clinicopathological features, diagnosis and differential diagnosis of ovarian cystic granulosa cell tumor. Methods: The clinical data of 1 patient with ovarian cystic granulosa cell tumor were reviewed. The gross and microscopic histopathological features and immunohistochemical staining of the tumor were reviewed. Results: The left single cystic granular cell tumor was 14.6 cm × 18.9 cm × 9.8 cm in size. The thickness of the cyst wall was not uniform. The inner wall of granulosa cell was composed of granulosa cells with different cell layers. The typical Call- Exner body; immunohistochemical staining showed α-inhibin, Vimentin, CD99 were positive. CONCLUSIONS: Ovarian cystic granulosa cell tumors can be diagnosed on the basis of characteristic histomorphology of atypical hyperplastic granulosa cells, typical Call-Exner bodies and nuclear ditches.