论文部分内容阅读
目的 探讨不同糖耐量孕妇血清脂联素与胰岛素抵抗和胰岛 β细胞分泌功能的关系。 方法 2 0 0 3年1月至 2 0 0 4年 1月广东省妇幼保健院和佛山市妇幼保健院采用稳态模型评估法 (HOMA)分别评估正常糖耐量孕妇 (NGT)、糖耐量减低孕妇 (GIGT)和妊娠期糖尿病患者 (GDM)的胰岛素抵抗指数 (HOMA IR)和胰岛 β细胞功能指数 (HBCI) ;利用放免法检测三组孕妇的血清脂联素水平。结果 (1)GDM组HOMA IR显著高于GIGT组 (P <0 0 5 )和NGT组 (P <0 0 0 1) ,三组的HBCI则差异无显著性。 (2 )血清脂联素水平由NGT、GIGI到GDM呈逐步下降态势 (P <0 0 0 1) ;多元回归分析提示HOMA IR、孕晚期体重、孕晚期BMI是影响血清脂联素水平的最显著因素(r2 =0 4 84 ,P <0 0 0 1)。结论 GDM和GIGT患者血清脂联素显著降低 ,并以GDM降低最为明显 ;其脂联素水平的改变与胰岛素敏感性高度相关。
Objective To investigate the relationship between serum adiponectin and insulin resistance and pancreatic β-cell secretory function in different glucose tolerance pregnant women. Methods From January 2003 to January 2004, Guangdong Provincial Maternal and Child Health Hospital and Foshan Maternal and Child Health Hospital evaluated the levels of normal glucose tolerance (NGT), impaired glucose tolerance (HOMA IR) and pancreatic β-cell function index (HBCI) in GIGT and GDM. Serum levels of adiponectin were detected by radioimmunoassay in three groups of pregnant women. Results (1) The HOMA IR of GDM group was significantly higher than that of GIGT group (P <0 05) and NGT group (P 0 001). The HBCI of three groups had no significant difference. (2) The level of serum adiponectin decreased gradually from NGT and GIGI to GDM (P <0.01). Multiple regression analysis indicated that HOMA IR, the third trimester of pregnancy, and the third trimester of pregnancy were the most influential factors of serum adiponectin Significant factors (r2 = 0 4 84, P <0 0 0 1). Conclusions The levels of serum adiponectin in GDM and GIGT patients were significantly lower than those in GDM patients, and the most significant decrease was GDM. The changes of adiponectin level were highly correlated with insulin sensitivity.