论文部分内容阅读
目的观察重组乙型肝炎疫苗(酵母)(YDV)免疫后8年的免疫记忆及抗体持久性。方法追踪观察按照免疫程序免疫后8年儿童的乙肝病毒表面抗体(抗-HBs)持久性;分别对免疫后4年和8年抗-Hbs阴转的儿童,加强免疫1剂,观察其免疫记忆反应。结果抗-HBs阳性率、有效阳性率、几何平均滴度逐年下降,分别由免疫后1年的92.08%、84.16%、29.21miU/ml降至8年后的65.17%、40.45%、5.38miU/ml;年均递减率分别为3.76%、7.82%、17.14%。抗-HBs阳性率下降速率较慢,而有效阳性率则较快,并随免疫时间的延长,各项指标的年均递减率逐年降低,推测免疫的低阳性率水平可能维持较长时间。结论 (YDV)免疫后存在较好的免疫记忆,免疫后8年无需加强免疫。
Objective To observe the immune memory and antibody persistence of recombinant hepatitis B vaccine (YDV) after 8 years of immunization. Methods The persistence of hepatitis B virus surface antibody (anti-HBs) was observed and observed in children after 8 years of immunization according to the immunization schedule. One immunization was boosted to children immunized with anti-HBs 4 and 8 years after immunization, and the immunological memory was observed reaction. Results The positive rate, effective positive rate and geometric mean titer of anti-HBs decreased year by year from 92.08%, 84.16% and 29.21miU / ml at 1 year after immunization to 65.17%, 40.45% and 5.38miU / ml; the average annual decline rates were 3.76%, 7.82%, 17.14% respectively. The positive rate of anti-HBs decreased slowly, but the positive rate of anti-HBs was relatively fast. With the extension of immunization time, the average declining rate of each index decreased year by year. It is presumed that the low positive rate of immunization may be maintained for a long time. Conclusions (YDV) immunization after good immune memory, 8 years after immunization without strengthening the immune.