Effect Evaluation of Strychnos nux-vomica L.with Integrative Methods for Bortezomib-Induced Peripher

• 作 者: DAI Tie-ying CHEN Chu-chu HONG Li-li Ge Hang-ping PEI Jun LYU Wen-qi YANG Xue SHEN Jian-ping HU Zhi-ping
• 机 构: Department of Hematology,the First Hospital Affiliated to Zhejiang University of Traditional Chinese
• 出 处: 中国结合医学杂志（英文版）
• 发表日期: 2021年2期
• 关键词: bortezomib-induced peripheral neuropathy grilled nux vomica total neuropathy sco

Objective:To explore the clinical effect and adverse reactions of Strychnos nux-vomica in bortezomib-induced peripheral neuropathy(BIPN)of patients with multiple myeloma(MM).Methods:A total of 19 MM patients with BIPN were enrolled and Nux Vomica Capsule(NVC,0.4 g,thrice daily)were orally administrated for 30 days.Comparative analysis on parameters between pre-and post-therapy,including peripheral neuropathy(PN)grade,neurotoxicity score,Chinese medicine(CM)syndrome score,total neuropathy score(TNS),coagulation function,and serum nerve growth factor(NGF)levels were conducted.The adverse events were monitored.Results:In BIPN of MM patients who received NVC,PN grade was lowered,neurotoxicity score was obviously decreased(P≤0.01),and both CM syndrome score and TNS were remarkably decreased(P＜0.01).After the therapy,activated partial thromboplastin time was prolonged(P＜0.01)and fibrinogen was declined(P＜0.05),showing improvement in the hypercoagulable state of patients.No significant difference of NGF recovery degrees was detected between pre-and post-therapy(P＞0.05).No evident adverse reactions were observed during the course of treatment.Conclusion:Strychnos nux-vomica L.has significantly effect with a good safety in treatment of BIPN in MM patients.