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目的通过对比分析奥美拉唑和泮托拉唑治疗残胃性食管反流的临床效果,为临床医师选择最佳治疗药物提供依据。方法选择本科2007年3月～2009年3月收治的42例残胃性食管反流患者,按用药方案抽取质子泵抑制剂药物奥美拉唑21例及泮托拉唑21例。分析对比两组治疗对烧心和反酸、吞咽困难和吞咽痛、胸骨后痛等症状;内镜下粘膜充血、水肿、渗出、糜烂、息肉样隆起等的效果。结果奥美拉唑与泮托拉唑的治疗效果总有效率分别为80.9%(32/42)、71.4%(30/42),奥美拉唑组明显高于泮托拉唑组,且差异有显著性。结论奥美拉唑是治疗残胃性食管反流比较理想的药物。
Objective To compare the clinical effects of omeprazole and pantoprazole in the treatment of gastric remnant esophageal reflux and provide evidence for clinicians to choose the best therapeutic drug. Methods Forty-two patients with residual esophageal reflux admitted to our hospital from March 2007 to March 2009 were enrolled. Twenty-one patients were treated with proton pump inhibitor omeprazole and 21 were treated with pantoprazole. Analysis and comparison of two groups of treatment of heartburn and acid reflux, dysphagia and swallowing pain, chest pain and other symptoms; endoscopic mucosal congestion, edema, exudation, erosion, polypoid uplift effect. Results The total effective rates of omeprazole and pantoprazole were 80.9% (32/42) and 71.4% (30/42), respectively. The omeprazole group was significantly higher than the pantoprazole group, and the difference was significant Sex. Conclusion Omeprazole is an ideal drug for the treatment of residual gastric esophageal reflux.