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本文比较了吡嗪酰胺(PZA)顿服及分服,血、脑脊液药物高峰浓度。结果:5例健康人和10例肺结核病人顿服后,血高峰浓度分别为43.46mg/L和43.14mg/L;分服为24.89mg/L和23.28mg/L。10例结脑病人脑脊液顿服及分服高峰浓度为42.94mg/L和23.57mg)L。顿服组药物高峰浓度超过PZA对大多数菌株的MIC水平(30mg/L),而分服均未达到。认为PZA应以顿服为宜。
This article compares the pyrazinamide (PZA) Dayton clothing and points service, blood, cerebrospinal fluid peak concentrations. Results: The peak blood concentrations were 43.46 mg / L and 43.14 mg / L respectively in 5 healthy people and 10 pulmonary tuberculosis patients. The divided doses were 24.89 mg / L and 23.28 mg / L. 10 patients with tuberculous cerebrospinal fluid Dayton service and sub-service peak concentrations of 42.94mg / L and 23.57mg) L. Dayton group peak drug concentration exceeds the PZA for most strains of MIC levels (30mg / L), while the sub-service were not met. Think PZA Dayton clothing should be appropriate.