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目的探讨内淋巴囊肿瘤(ELST)的病理形态特点、组织发生、诊断和鉴别诊断、治疗及预后,提高对该罕见肿瘤的认识。方法对1例ELST患者临床及病理资料进行分析,并行HE染色和免疫组化EnVision二步法。结果肿瘤大多数区域呈乳头状囊状结构,乳头状结构被覆无纤毛的单层立方-柱状上皮;部分区域呈腺样并呈囊性扩张,其内可见粉染的胶样物质,类似甲状腺滤泡内胶质。免疫组化示瘤细胞EMA、NSE、vimentin、VEGF、CK5/6和CK8/18(+)。结论 ELST较为罕见,临床及病理均易与其他肿瘤混淆,需要常规病理结合免疫组化进行诊断及鉴别诊断。
Objective To investigate the pathological features of endolymphatic cyst tumor (ELST), its occurrence, diagnosis and differential diagnosis, treatment and prognosis, and to raise awareness of this rare tumor. Methods One case of ELST patients with clinical and pathological data were analyzed, parallel HE staining and immunohistochemistry EnVision two-step method. Results Most of the tumors showed papillary cystic structures, the papillary structures were covered with cilia-free single-layer cubic-columnar epithelium. Some areas were adenoid and showed cystic dilatation. The gland-like material like thyroid gland Bubble gum. Immunohistochemistry showed tumor cells EMA, NSE, vimentin, VEGF, CK5 / 6 and CK8 / 18 (+). Conclusion ELST is relatively rare, clinical and pathological confusion with other tumors, the need for routine pathological immunohistochemical diagnosis and differential diagnosis.