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目的:探讨CD117和CD34在胃肠道间质瘤(GISTs)中的表达及其临床意义。方法:应用免疫组织化学方法检测CD117和CD34在46例GISTs患者手术切除肿瘤组织和24例真性平滑肌瘤(对照组)中的表达,并观察GISTs的病理学特征。结果:GISTs患者手术切除肿瘤组织在光镜下主要由数量不等的梭形和(或)上皮样细胞组成,梭形细胞排列成束状、编织状或旋涡状,上皮样细胞多呈弥漫片状、束状或巢状排列,两种细胞可按不同比例混合性或单一性组成肿瘤的实体。GISTs组织中CD117、CD34阳性表达率分别为100.0%、84.8%,对照组真性平滑肌瘤组织中CD117和CD34均无表达。GISTs主要发生在胃(52.2%,24/46)和小肠(26.1%,12/46)。结论:CD117和CD34是诊断GISTs比较特异性的抗体,具有非常重要的诊断价值。
Objective: To investigate the expression of CD117 and CD34 in gastrointestinal stromal tumors (GISTs) and its clinical significance. Methods: Immunohistochemistry was used to detect the expression of CD117 and CD34 in the resected tumor tissue and 24 cases of true leiomyoma (control group) in 46 cases of GISTs. The pathological features of GISTs were also observed. Results: Surgical resection of tumor tissue in GISTs mainly consisted of fusiform and / or epithelioid cells in varying degrees under light microscopy. The spindle cells were arranged in a bundle, braided or whirlpool. Most epithelial-like cells were diffuse Orbicular, fascicular or nested arrangement, the two kinds of cells can be mixed in different proportions or single entity composed of tumors. The positive rates of CD117 and CD34 in GISTs tissues were 100.0% and 84.8%, respectively. There was no expression of CD117 and CD34 in the true leiomyoma of the control group. GISTs mainly occurred in the stomach (52.2%, 24/46) and small intestine (26.1%, 12/46). Conclusion: CD117 and CD34 are relatively specific antibodies for the diagnosis of GISTs and have a very important diagnostic value.