,R-loop: an emerging regulator of chromatin dynamics

• 作 者: Qais Al-Hadid Yanzhong Yang
• 机 构: Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope Cancer Cente
• 出 处: 生物化学与生物物理学报（英文版）
• 发表日期: 2016年7期
• 关键词: DNA-RNA hybrid R-loop epigenetic modification transcription

The dynamic structure of chromatin,which exists in two conformational states:heterochromatin and euchromatin,alters the accessibility of the DNA to regulatory factors during transcription,replication,recombination,and DNA damage repair.Chemical modifications of histones and DNA,as well as adenosine triphospahate-dependent nucleosome remodeling,have been the major focus of research on chromatin dynamics over the past two decades.However,recent studies using a DNA-RNA hybrid-specific antibody and next-generation seque,ncing approaches have revealed that the formation of R-loops,one of the most common non-canonical DNA structures,is an emerging regulator of chromatin states.This review focuses on recent insights into the interplay between R-loop formation and the epigenetic modifications of chromatin in normal and disease states.