论文部分内容阅读
目的观察早期胰岛素强化治疗对新诊断2型糖尿病(T2DM)患者长期血糖控制的影响。方法随访15例接受早期胰岛素强化治疗后缓解的T2DM患者,观察血糖、HOMA-IR和HOMA-IS的变化趋势。结果 15例T2DM患者在胰岛素强化治疗后的12个月、24个月、36个月时,能仅通过饮食控制而保持血糖稳态的患者例数分别是12(80.0%)、8(53.3%)、6(40.0%);在平均33个月时持续缓解组与失败组HOMA-IR和HOMA-IS差异有统计学意义,HOMA-IR分别为5.4±3.4和10.3±6.6,HOMA-IS分别为383.5±389.1和192.4±195.3(P<0.05)。结论通过消除葡萄糖毒性,恢复血糖刺激的胰岛素第一时相分泌,早期胰岛素强化治疗可以延长T2DM自然病史的早期阶段。
Objective To observe the effect of early intensive insulin therapy on long-term glycemic control in newly diagnosed type 2 diabetes mellitus (T2DM). Methods Fifteen patients with T2DM who underwent remission after early intensive insulin therapy were followed up. The changes of blood glucose, HOMA-IR and HOMA-IS were observed. Results In 15 T2DM patients, 12 (80.0%) and 8 (53.3%) patients were able to maintain their glycemic homeostasis only through diet control at 12 months, 24 months and 36 months after insulin therapy. ), 6 (40.0%). There was significant difference between HOMA-IR and HOMA-IS in continuous remission group and failure group at an average of 33 months, HOMA-IR was 5.4 ± 3.4 and 10.3 ± 6.6 383.5 ± 389.1 and 192.4 ± 195.3 (P <0.05). Conclusion By eliminating glucose toxicity and restoring glucose-stimulated insulin first-phase secretion, early insulin-intensive therapy can prolong the early stages of T2DM natural history.